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I'd love it if when you hit CTL-S within a map file that you opened (not a brand new map) you wouldn't be prompted to Save As.
I have to take responsibility for this, sure, but that feature has made me save over the wrong map file a couple of times now and it's very frustrating to lose the work. If hit Save in a file I opened, it's a given I want to save over said file, you know?